LY2322600
| CAS号 | 862505-01-9 | 货号 | BCP27665 |
| 中文名 | LY2322600 | ||
| 英文名 | LY2322600 | ||
| 中文别名 | |||
| 英文别名 | LY 2322600;LY-2322600; | ||
| 分子式 | C25H33FN6O3S | 分子量 | 516.64 |
| 生物活性 | LY2228820 is a novel and potent p38MAPK inhibitor. In vitro kinase enzyme activity showed that the IC50 for p38αMAPK and p38βMAPK of LY2228820 were 7 nM and 3 nM, respectively. Phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, was significantly inhibited by LY in both MM cell lines and LT-BMSCs. | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | p38 MAPK | ||
结构式
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