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Pexmetinib 结构式

Pexmetinib

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货号 :BCP28410CAS号 :945614-12-0纯度:98%
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  • 基本信息与产品描述
CAS号 945614-12-0 货号 BCP28410
中文名 Pexmetinib
英文名 Pexmetinib
中文别名
英文别名 ARRY614; ARRY-614; ARRY 614;
SMILES CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NCC3=C(C=CC(=C3)F)OC4=CC5=C(C=C4)N(N=C5)CCO
化学名称
分子式 C31H33FN6O3 分子量 556.63
纯度 98% 配送 惯例下常温包邮
产品描述 Pexmetinib, also known as ARRY-614, is an orally bioavailable small-molecule inhibitor of p38 and Tie2 kinases with potential antineoplastic, anti-inflammatory and antiangiogenic activities. p38/Tie2 kinase inhibitor Arry-614 binds to and inhibits the activities of p38 and Tie2 kinases, which may inhibit the production of proinflammatory cytokines and may decrease tumor angiogenesis and tumor cell growth and survival. p38 is a MAP kinase that is often upregulated in cancer cells, playing a crucial part in the production of a variety of cytokines involved in inflammation and cellular proliferation such as tumor necrosis factor (TNF) and interleukin (IL)-1 and -6. Tie2 is an endothelial cell specific receptor that is activated by angiopoietins, growth factors required for angiogenesis.
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