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CAS号 | 81872-10-8 | 货号 | BCP09233 |
中文名 | 佐芬普利 | ||
英文名 | Zofenopril | ||
中文别名 | |||
英文别名 | Zofenoprilum;SQ 26900;SQ-26900;SQ26900;(4S)-1-[(2S)-3-(Benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)-L-proline; | ||
SMILES | CC(CSC(=O)C1=CC=CC=C1)C(=O)N2CC(CC2C(=O)O)SC3=CC=CC=C3 | ||
化学名称 | |||
分子式 | C22H23NO4S2 | 分子量 | 429.56 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Zofenopril is a sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zofenopril is hydrolyzed in vivo into its active form zofenoprilat. Zofenoprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zofenoprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. |
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