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Bisantrene 结构式

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货号 :BCP20206CAS号 :78186-34-2纯度:98%
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  • 基本信息与产品描述
CAS号 78186-34-2 货号 BCP20206
关联产品 71439-68-4(比生群二盐酸盐)
中文名 比生群
英文名 Bisantrene
中文别名
英文别名
SMILES
化学名称
分子式 C22H22N8 分子量 398.46
纯度 98% 配送 惯例下常温包邮
产品描述 Bisantrene shows an outstanding ability to form a complex with DNA. Bisantrene exhibits the most effective binding (even neglecting electrostatic contacts), followed by the 9-substituted compounds and finally by 1-IHA. Bisantrene congeners retained a remarkable capacity for binding to the single-stranded structure. In comparison with the Ki values found for double-stranded DNA, 9-IHA shows a 2-fold increase, 1-IHA maintains the same values, and aza-9-IHA exhibits a modest reduction. On the other hand, Bisantrene, although undergoing a 6-fold reduction in Ki, still exhibits an affinity constant of the order of 106 M-1. Bisantrene promots DNase I cleavage at oligopurine-oligopyrimidine tracts; conversely, it slightly reduces the cleavage activity at alternating purine-pyrimidine sequences. Bisantrene is an active new drug in the treatment of metastatic breast cancer. Bisantrene is an inhibitor of [3H]uridine incorporation into RNA and [3H]thymidine incorporation into DNA.
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