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CAS号 | 78186-34-2 | 货号 | BCP20206 |
关联产品 | 71439-68-4(比生群二盐酸盐) | ||
中文名 | 比生群 | ||
英文名 | Bisantrene | ||
中文别名 | |||
英文别名 | |||
SMILES | |||
化学名称 | |||
分子式 | C22H22N8 | 分子量 | 398.46 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Bisantrene shows an outstanding ability to form a complex with DNA. Bisantrene exhibits the most effective binding (even neglecting electrostatic contacts), followed by the 9-substituted compounds and finally by 1-IHA. Bisantrene congeners retained a remarkable capacity for binding to the single-stranded structure. In comparison with the Ki values found for double-stranded DNA, 9-IHA shows a 2-fold increase, 1-IHA maintains the same values, and aza-9-IHA exhibits a modest reduction. On the other hand, Bisantrene, although undergoing a 6-fold reduction in Ki, still exhibits an affinity constant of the order of 106 M-1. Bisantrene promots DNase I cleavage at oligopurine-oligopyrimidine tracts; conversely, it slightly reduces the cleavage activity at alternating purine-pyrimidine sequences. Bisantrene is an active new drug in the treatment of metastatic breast cancer. Bisantrene is an inhibitor of [3H]uridine incorporation into RNA and [3H]thymidine incorporation into DNA. |
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