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CAS号 | 677017-23-1 | 货号 | BCP41505 |
中文名 | Berubicin | ||
英文名 | Berubicin | ||
中文别名 | |||
英文别名 | RTA-744; RTA 744; RTA774; WP 769; WP769; WP-769; | ||
SMILES | CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)OCC6=CC=CC=C6 | ||
化学名称 | |||
分子式 | C34H35NO11 | 分子量 | 633.64 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Berubicin is a 4'-O-benzylated analogue of the anthracycline derivative doxorubicin, with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, as well as RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB) and can circumvent P glycoprotein/MRP1-mediated efflux. |
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