Berubicin
CAS号 | 677017-23-1 | 货号 | BCP41505 |
中文名 | Berubicin | ||
英文名 | Berubicin | ||
中文别名 | |||
英文别名 | RTA-744; RTA 744; RTA774; WP 769; WP769; WP-769; | ||
分子式 | C34H35NO11 | 分子量 | 633.64 |
生物活性 | Berubicin is a 4'-O-benzylated analogue of the anthracycline derivative doxorubicin, with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, as well as RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB) and can circumvent P glycoprotein/MRP1-mediated efflux. | ||
信号通路 | Cell Cycle/DNA Damage | ||
靶 点 | Topoisomerase |
结构式
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