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CAS号 | 667880-38-8 | 货号 | BCP36163 |
中文名 | ZLDI-8 | ||
英文名 | ZLDI-8 | ||
中文别名 | |||
英文别名 | ZLDI 8; ZLDI8; | ||
SMILES | CC1=CC(=C(C=C1)OCCN2C(=C(C3=CC=CC=C32)C=C4C(=O)NC(=S)NC4=O)C)C | ||
化学名称 | |||
分子式 | C24H23N3O3S | 分子量 | 433.52 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | ZLDI-8 is a Notch activating/cleaving enzyme ADAM-17 inhibitor and inhibits the cleavage of Notch protein. ZLDI-8 decreases the expression of pro-survival/anti-apoptosis and epithelial-mesenchymal transition (EMT) related proteins. ZLDI-8 is also a competitive and irreversible tyrosine phosphatase (Lyp) inhibitor with an IC50 of 31.6 μM and a Ki of 26.22 μM. ZLDI-8 inhibits the growth of MHCC97-H cells with an IC50 of 5.32 μM. |
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