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| CAS号 | 1922098-69-8 | 货号 | BCP31985 |
| 中文名 | CCG-222740 | ||
| 英文名 | CCG-222740 | ||
| 中文别名 | |||
| 英文别名 | CCG 222740; CCG222740; | ||
| SMILES | C1C(CN(CC1(F)F)C(=O)C2=CC=CC(=C2)C3=CC=CO3)C(=O)NC4=CC=C(C=C4)Cl | ||
| 化学名称 | |||
| 分子式 | C23H19ClF2N2O3 | 分子量 | 444.86 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | CCG-222740 is a potent MRTF/SRF inhibitor. CCG-222740 markedly decreased SRF reporter gene activity and showed a greater inhibitory effect on MRTF/SRF target genes than the previously described MRTF-A inhibitor CCG-203971. CCG-222740 was also five times more potent, with an IC50 of 5 μM, in a fibroblast-mediated collagen contraction assay, was less cytotoxic, and a more potent inhibitor of alpha-smooth muscle actin protein expression than CCG-203971. | ||
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