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CAS号 | 2937327-93-8 | 货号 | BCP49601 |
中文名 | BI-2865 | ||
英文名 | BI-2865 | ||
中文别名 | |||
英文别名 | BI 2865;BI2865; | ||
SMILES | CC(C1CCCN1C)OC2=NC(=NC=C2)C3=NOC(=N3)C4(CCCC5=C4C(=C(S5)N)C#N)C | ||
化学名称 | |||
分子式 | C23H27N7O2S | 分子量 | 465.57 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM). |
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