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CHIR-99021 HCl 结构式

CHIR-99021盐酸盐

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货号 :BCP26126CAS号 :1797989-42-4纯度:98%
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  • 基本信息与产品描述
CAS号 1797989-42-4 货号 BCP26126
中文名 CHIR-99021盐酸盐
英文名 CHIR-99021 HCl
中文别名
英文别名 CHIR-911; CHIR911; CHIR 911; CT- 99021; CT-99021; CT- 99021; CHIR-73911; CHIR73911; CHIR 73911; GSK 3 inhibitor XVI; GSK 3IXV; CHIR99021; CHIR 99021;
SMILES N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl
化学名称
分子式 C22H19Cl3N8 分子量 501.8
纯度 98% 配送 惯例下常温包邮
产品描述 CHIR99021, also known as CT99021, is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM. CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression.
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