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CAS号 | 1782235-14-6 | 货号 | BCP26069 |
中文名 | CHIR-99021 trihydrochloride | ||
英文名 | CHIR-99021 trihydrochloride | ||
中文别名 | |||
英文别名 | CT99021 trihydrochloride;CHIR-99021 3HCl; GSK 3 inhibitor XVI; GSK 3IXV; | ||
SMILES | CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl.Cl.Cl | ||
化学名称 | |||
分子式 | 分子量 | 574.72 | |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | CHIR-99021 trihydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. CHIR-99021 trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. CHIR-99021 trihydrochloride is also a potent Wnt/β-catenin signaling pathway activator. CHIR-99021 trihydrochloride enhances mouse and human embryonic stem cells self-renewal. CHIR-99021 trihydrochloride induces autophagy. |
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