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CAS号 | 1962178-27-3 | 货号 | BCP44964 |
中文名 | PF-04802367 | ||
英文名 | PF-04802367 | ||
中文别名 | |||
英文别名 | PF04802367;PF 04802367;PF367;PF 367;PF-367; | ||
SMILES | COC1=C(C=C(C=C1)C2=C(N=CO2)C(=O)NCCCN3C=NC=N3)Cl | ||
化学名称 | |||
分子式 | C16H16ClN5O3 | 分子量 | 361.78 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. PF-04802367 shows desirable central nervous system (CNS) properties and potency. PF-04802367 is equally effective at inhibition of the two known GSK-3 isoforms (GSK-3α and GSK-3β) with IC50 values of 10.0 and 9.0 nM in mobility shift assays, respectively[1]. |
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