CHIR-99021盐酸盐
CAS号 | 1797989-42-4 | 货号 | BCP26126 |
中文名 | CHIR-99021盐酸盐 | ||
英文名 | CHIR-99021 HCl | ||
中文别名 | |||
英文别名 | CHIR-911; CHIR911; CHIR 911; CT- 99021; CT-99021; CT- 99021; CHIR-73911; CHIR73911; CHIR 73911; GSK 3 inhibitor XVI; GSK 3IXV; CHIR99021; CHIR 99021; | ||
分子式 | C22H19Cl3N8 | 分子量 | 501.8 |
生物活性 | CHIR99021, also known as CT99021, is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10μM. CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression. | ||
信号通路 | Wnt/Stem Cell PI3K/Akt/mTOR | ||
靶 点 | GSK3 |
结构式
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