LY3143921 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP48019CAS号：1627696-52-9纯度：98%

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CAS号	1627696-52-9	货号	BCP48019
关联产品	1627696-51-8（LY-3177833） 1627696-53-0（LY3143921 hydrate）
中文名	LY3143921
英文名	LY3143921
中文别名
英文别名	LY-3143921;LY 3143921;(S)-LY3177833;
SMILES	CC1(C2=C(C=C(C=C2)C3=CNN=C3)C(=O)N1)C4=NC=NC=C4F
化学名称
分子式	C16H12FN5O	分子量	309.3
纯度	98%	配送	惯例下常温包邮
产品描述	LY3143921 is a potent and selective CDC7 kinase inhibitor. LY3143921 targets, binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. The serine-threonine kinase CDC7 plays a key role in DNA replication by binding to and phosphorylating serine (Ser)-40 and 53 of MCM2 (minichromosome maintenance complex component 2), which is required for the initiation of DNA replication. Although expressed at low levels in healthy, normal cells, CDC7 is expressed at much higher levels in cancer cells.