LY3143921
| CAS号 | 1627696-52-9 | 货号 | BCP48019 |
| 中文名 | LY3143921 | ||
| 英文名 | LY3143921 | ||
| 中文别名 | |||
| 英文别名 | LY-3143921;LY 3143921;(S)-LY3177833; | ||
| 分子式 | C16H12FN5O | 分子量 | 309.3 |
| 生物活性 | LY3143921 is a potent and selective CDC7 kinase inhibitor. LY3143921 targets, binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. The serine-threonine kinase CDC7 plays a key role in DNA replication by binding to and phosphorylating serine (Ser)-40 and 53 of MCM2 (minichromosome maintenance complex component 2), which is required for the initiation of DNA replication. Although expressed at low levels in healthy, normal cells, CDC7 is expressed at much higher levels in cancer cells. | ||
| 上下游产品 | 1627696-51-8（LY-3177833） 1627696-53-0（LY3143921 hydrate） | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | CDK | ||
结构式
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