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CAS号 | 294646-77-8 | 货号 | BCP45443 |
关联产品 | 1786438-30-9((R)-CR8 trihydrochloride) | ||
中文名 | (R)-CR8 | ||
英文名 | (R)-CR8 | ||
中文别名 | |||
英文别名 | CR8, (R)-Isomer; (R)-CR-8; (R)-CR 8; | ||
SMILES | CCC(CO)NC1=NC(=C2C(=N1)N(C=N2)C(C)C)NCC3=CC=C(C=C3)C4=CC=CC=N4 | ||
化学名称 | |||
分子式 | C24H29N7O | 分子量 | 431.53 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | (R)-CR8 (CR8), a second-generation analog of Roscovitine, is a potent CDK1/2/5/7/9 inhibitor. (R)-CR8 inhibits CDK1/cyclin B (IC50=0.09 μM), CDK2/cyclin A (0.072 μM), CDK2/cyclin E (0.041 μM), CDK5/p25 (0.11 μM), CDK7/cyclin H (1.1 μM), CDK9/cyclin T (0.18 μM) and CK1δ/ε (0.4 μM). (R)-CR8 induces apoptosis and has neuroprotective effect. (R)-CR8 acts as a molecular glue degrader that depletes cyclin K. |
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