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Fingolimod HCl 结构式

盐酸芬戈莫德

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货号 :BCP01808CAS号 :162359-56-0纯度:98%
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  • 基本信息与产品描述
CAS号 162359-56-0 货号 BCP01808
中文名 盐酸芬戈莫德
英文名 Fingolimod HCl
中文别名
英文别名 Fingolimod;Gilenia;FTY720; FTY-720; FTY 720;Fingolimod hydrochloride;
SMILES
化学名称
分子式 C19H33NO2.HCl 分子量 343.93
纯度 98% 配送 惯例下常温包邮
产品描述 The inhibitory effect of S1P is revered by various concentrations of FTY720, with IC50 effect of 173 nM. In addition, FTY720 (10 nM) alone exerts no effect on the expression of co-stimulatory molecules. FTY720 reverses the increased expression of HLA-I induced by S1P for both the percentages of cells and the MFI, upon comparing the effect of S1P to the effect of combining S1P with FTY720.Medium and high-dose FTY720-P also enhances the levels of TGF-β1. TGF-β1 and Foxp3 mRNA expression are upregulated in the high-dose FTY720-P group. The proliferation of effector T cells is suppressed significantly in the medium and high-dose FTY720-P group at a Treg/Teff cell ratio of 1:1. At a ratio of 1:1, the proliferation of effector T cells is also suppressed in the high-dose FTY720 group.
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