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PD 166285 dihydrochloride 结构式

PD 166285 dihydrochloride

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货号 :BCP22349CAS号 :212391-63-4纯度:98%
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  • 基本信息与产品描述
CAS号 212391-63-4 货号 BCP22349
中文名 PD 166285 dihydrochloride
英文名 PD 166285 dihydrochloride
中文别名
英文别名 PD-166285 dihydrochloride;PD-166285 2HCl;PD166285 dihydrochloride;
SMILES CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl.Cl.Cl
化学名称
分子式 C26H29Cl4N5O2 分子量 585.35
纯度 98% 配送 惯例下常温包邮
产品描述 PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint.
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