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CAS号 | 212391-63-4 | 货号 | BCP22349 |
中文名 | PD 166285 dihydrochloride | ||
英文名 | PD 166285 dihydrochloride | ||
中文别名 | |||
英文别名 | PD-166285 dihydrochloride;PD-166285 2HCl;PD166285 dihydrochloride; | ||
SMILES | CCN(CC)CCOC1=CC=C(C=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl.Cl.Cl | ||
化学名称 | |||
分子式 | C26H29Cl4N5O2 | 分子量 | 585.35 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. |
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