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CAS号 | 869748-10-7 | 货号 | BCP30674 |
中文名 | A-770041 | ||
英文名 | A-770041 | ||
中文别名 | |||
英文别名 | A 770041; A770041; | ||
SMILES | CC(=O)N1CCN(CC1)C2CCC(CC2)N3C4=C(C(=N3)C5=CC(=C(C=C5)NC(=O)C6=CC7=CC=CC=C7N6C)OC)C(=NC=N4)N | ||
化学名称 | |||
分子式 | C34H39N9O3 | 分子量 | 621.74 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | A-770041 is a potent ans selective LCK inhibitor. Concanavalin A-stimulated IL-2 production in whole blood is inhibited by A-770041 with an EC50 of approximately 80 nM. A-770041 is orally bioavailable (F = 34.1 +/- 7.2% at 10 mg/kg) and has a t(1/2) of 4.1 +/- 0.1 h. Concanavalin A-induced IL-2 production in vivo is inhibited by oral administration of A-770041 (in vivo EC50 = 78 +/- 28 nM). A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells. A-770041 prevents organ allograft rejection. |
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