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Vodobatinib 结构式

Vodobatinib

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货号 :BCP43522CAS号 :1388803-90-4纯度:98%
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  • 基本信息与产品描述
CAS号 1388803-90-4 货号 BCP43522
中文名 Vodobatinib
英文名 Vodobatinib
中文别名
英文别名 K-0706; K0706; K0706;
SMILES CC1=C(C(=CC=C1)Cl)C(=O)NNC(=O)C2=CC(=C(C=C2)C)C#CC3=CC4=CC=CC=C4N=C3
化学名称
分子式 C27H20ClN3O2 分子量 453.92
纯度 98% 配送 惯例下常温包邮
产品描述 Vodobatinib is an orally bioavailable, Bcr-Abl tyrosine kinase inhibitor (TKI), with potential antineoplastic activity. Upon administration, vodobatinib selectively targets and binds to the Bcr-Abl fusion oncoprotein, including various Bcr-Abl mutant forms, such as those with the 'gatekeeper' resistance mutation T315I. This inhibits proliferation of Bcr-Abl-expressing tumor cells. The Bcr-Abl fusion protein is an aberrantly activated tyrosine kinase produced by certain leukemia cells. T315I, an amino acid substitution where threonine (T) has been mutated to isoleucine (I) at position 315 in the tyrosine-protein kinase ABL1 portion of the Bcr-Abl fusion protein, plays a key role in resistance to certain chemotherapeutic agents and its expression is associated with poor prognosis.
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