HDM-201
| CAS号 | 1448867-41-1 | 货号 | BCP20814 |
| 中文名 | HDM-201 | ||
| 英文名 | HDM201 | ||
| 中文别名 | |||
| 英文别名 | Siremadlin; HDM 201; HDM-201; NVP-HDM201; NVP-HDM-201; NVP-HDM 201; | ||
| 分子式 | C26H24Cl2N6O4 | 分子量 | 555.42 |
| 生物活性 | HDM201 is an orally bioavailable human double minute 2 homolog (HDM2) inhibitor with potential antineoplastic activity. HDM2 inhibitor HDM201 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of both p53 signaling and p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | Mdm2 p53 | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！