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| CAS号 | 1448428-04-3 | 货号 | BCP17814 |
| 中文名 | 司隆色替 | ||
| 英文名 | Selonsertib | ||
| 中文别名 | 瑟隆舍替; | ||
| 英文别名 | GS-4997; GS4997; GS 4997; | ||
| SMILES | O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F | ||
| 化学名称 | |||
| 分子式 | C24H24FN7O | 分子量 | 445.49 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation. | ||
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