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CAS号 | 1448428-05-4 | 货号 | BCP20629 |
中文名 | GS-4997 HCl salt | ||
英文名 | GS-4997 HCl salt | ||
中文别名 | |||
英文别名 | GS-4997; GS4997; GS 4997; Selonsertib; | ||
SMILES | |||
化学名称 | |||
分子式 | C24H25ClFN7O | 分子量 | 481.96 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation. |
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