司隆色替
| CAS号 | 1448428-04-3 | 货号 | BCP17814 |
| 中文名 | 司隆色替 | ||
| 英文名 | Selonsertib | ||
| 中文别名 | 瑟隆舍替; | ||
| 英文别名 | GS-4997; GS4997; GS 4997; | ||
| 分子式 | C24H24FN7O | 分子量 | 445.49 |
| 生物活性 | Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation. | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | MAP3K | ||
结构式
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