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CAS号 | 1433497-19-8 | 货号 | BCP20655 |
中文名 | LY2955303 | ||
英文名 | LY2955303 | ||
中文别名 | |||
英文别名 | LY-2955303; LY 2955303; | ||
SMILES | |||
化学名称 | |||
分子式 | C36H42N4O3 | 分子量 | 578.74 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | LY2955303 is a potent and selective RAR-gamma antagonist for the treatment of osteoarthritis pain. LY2955303 has RAR-gamma Ki = 1.09 nM; RAR-alpha Ki > 1700 nM; RAR-beta Ki > 2980 nM. LY2955303 demonstrated good pharmacokinetic properties and was efficacious in the MIA model of osteoarthritis-like joint pain. LY2955303 demonstrated an improved margin to RAR -mediated adverse effects. |
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