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| CAS号 | 1345847-93-9 | 货号 | BCP15682 |
| 中文名 | 奥曲替尼 | ||
| 英文名 | Altiratinib | ||
| 中文别名 | |||
| 英文别名 | DCC-2701;DCC 2701;DCC2701; DP 5164; DP5164; DP-5164; | ||
| SMILES | C1CC1C(=O)NC2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F)F | ||
| 化学名称 | |||
| 分子式 | C26H21F3N4O4 | 分子量 | 510.64 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Altiratinib, also known as DCC-270, DP-5164, is an oral, selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. DCC-2701 effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Importantly, DCC-2701's anti-proliferative activity was dependent on c-MET activation induced by stromal human fibroblasts and to a lesser extent exogenous HGF. | ||
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