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S1RA hydrochloride 结构式

S1RA hydrochloride

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货号 :BCP24076CAS号 :1265917-14-3纯度:98%
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  • 基本信息与产品描述
CAS号 1265917-14-3 货号 BCP24076
中文名 S1RA hydrochloride
英文名 S1RA hydrochloride
中文别名
英文别名 E52862 HCl;E-52862 hydrochloride;; E-52862 HCl; E 52862 hydrochloride; S1RA hydrochloride;
SMILES CC1=CC(OCCN2CCOCC2)=NN1C3=CC(C=CC=C4)=C4C=C3.[H]Cl
化学名称
分子式 C20H24ClN3O2 分子量 373.88
纯度 98% 配送 惯例下常温包邮
产品描述 S1RA Hcl(E-52862 Hcl) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).E-52862, also known as S1RA, is a selective sigma-1 receptor antagonist, with a reported binding affinity of Ki = 17.0 ± 7.0 nM, selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. In preclinical studies, S1RA has demonstrated efficacy in relieving neuropathic pain and pain in other sensitizing conditions, associated with an improvement of the emotional negative state. E-52862 attenuates neuropathic pain of different aetiology in rats.
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