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LCH-7749944 结构式

LCH-7749944

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货号 :BCP46494CAS号 :796888-12-5纯度:98%
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  • 基本信息与产品描述
CAS号 796888-12-5 货号 BCP46494
中文名 LCH-7749944
英文名 LCH-7749944
中文别名
英文别名 LCH 7749944; LCH7749944; GNF-PF-2356;
SMILES COC1=CC=CC(=C1)NC2=NC3=CC=CC=C3C(=N2)NCC4CCCO4
化学名称
分子式 C20H22N4O2 分子量 350.41
纯度 98% 配送 惯例下常温包邮
产品描述 LCH-7749944 is a novel and potent PAK4 inhibitor, which effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway. In addition, LCH-7749944 significantly inhibited the migration and invasion of human gastric cancer cells in conjunction with concomitant blockage of PAK4/LIMK1/cofilin and PAK4/MEK-1/ERK1/2/MMP2 pathways. Interestingly, LCH-7749944 also inhibited the formation of filopodia and induced cell elongation in SGC7901 cells. Importantly, LCH-7749944 caused successful inhibition of EGFR activity due to its inhibitory effect on PAK4. Taken together, these results provided novel insights into the development of PAK4 inhibitor and potential therapeutic strategies for gastric cancer.
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