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FRAX486 结构式

FRAX486

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货号 :BCP13764CAS号 :1232030-35-1纯度:98%
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  • 基本信息与产品描述
CAS号 1232030-35-1 货号 BCP13764
中文名 FRAX486
英文名 FRAX486
中文别名
英文别名 FRAX-486;FRAX 486;
SMILES
化学名称
分子式 C25H23Cl2FN6O 分子量 513.39
纯度 98% 配送 惯例下常温包邮
产品描述 in vitro: FRAX486 is an inhibitor of PAK, with excellent selectivity for group I over group II PAKs [1]. Different from W-7 and KN-62, FRAX355 and FRAX486 did not completely block the NMDA-R activation-mediated spine enlargement in the presence of control RNAi, suggesting that these FRAX compounds act less aversely to the synaptic plasticity. in vivo: Mice were administered FRAX486 at a concentration of 20 mg/kg, and brain tissue was collected 8 h after drug treatment. Indeed, the phenotype was rescued by treatment with FRAX486 8 h after a single treatment because spine density was decreased to levels similar to WT mice but significantly lower than untreated Fmr1 KO mice. FRAX486 also decreased spine density in Fmr1 KO mice in the neighboring segment. FRAX486 does not have an effect in segments 1–2 and 5–10, in which there is no phenotype in the mutant mice .
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