即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS号 | 1232030-35-1 | 货号 | BCP13764 |
中文名 | FRAX486 | ||
英文名 | FRAX486 | ||
中文别名 | |||
英文别名 | FRAX-486;FRAX 486; | ||
SMILES | |||
化学名称 | |||
分子式 | C25H23Cl2FN6O | 分子量 | 513.39 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | in vitro: FRAX486 is an inhibitor of PAK, with excellent selectivity for group I over group II PAKs [1]. Different from W-7 and KN-62, FRAX355 and FRAX486 did not completely block the NMDA-R activation-mediated spine enlargement in the presence of control RNAi, suggesting that these FRAX compounds act less aversely to the synaptic plasticity. in vivo: Mice were administered FRAX486 at a concentration of 20 mg/kg, and brain tissue was collected 8 h after drug treatment. Indeed, the phenotype was rescued by treatment with FRAX486 8 h after a single treatment because spine density was decreased to levels similar to WT mice but significantly lower than untreated Fmr1 KO mice. FRAX486 also decreased spine density in Fmr1 KO mice in the neighboring segment. FRAX486 does not have an effect in segments 1–2 and 5–10, in which there is no phenotype in the mutant mice . |
相关产品推荐
查看更多 >Tags:FRAX486 供应商,FRAX486 购买,FRAX486 生产,FRAX486 批量,FRAX486 供应,FRAX486 订购,FRAX486 采购