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CAS号 | 500-38-9 | 货号 | BCP08590 |
中文名 | 去甲二氢愈创木酸 | ||
英文名 | Nordihydroguaiaretic acid | ||
中文别名 | |||
英文别名 | NDGA;Masoprocol; | ||
SMILES | CC(CC1=CC=C(O)C(O)=C1)C(C)CC2=CC=C(O)C(O)=C2 | ||
化学名称 | |||
分子式 | C18H22O4 | 分子量 | 302.36 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Nordihydroguaiaretic acid, also known as NDGA, is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. NDGA directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, NDGA inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrines; it may prevent leukocyte infiltration into tissues and the release of reactive oxygen species and, at higher concentrations, may also inhibit cyclooxygenase. |
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