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Zileuton 结构式

齐留通

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货号 :BCP16199CAS号 :111406-87-2纯度:98%
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  • 基本信息与产品描述
CAS号 111406-87-2 货号 BCP16199
中文名 齐留通
英文名 Zileuton
中文别名
英文别名 Zyflo;A 64077;Abbott 64077;Griluto-CR;Leutrol;
SMILES
化学名称
分子式 C11H12N2O2S 分子量 236.29
纯度 98% 配送 惯例下常温包邮
产品描述 in vitro: Zileuton inhibited 5-hydroxyeicosatetraenoic acid synthesis by rat basophilic leukemia cell 20,000 x g supernatant and rat polymorphonuclear leukocytes (PMNL) (IC50 = 0.5 and 0.3 microM) respectively. It also inhibited leukotriene (LT)B4 biosynthesis by rat PMNL (IC50 = 0.4 microM), human PMNL (IC50 = 0.4 microM) and human whole blood (IC50 = 0.9 microM) [1]. Zileuton inhibited antigen-induced contractions of guinea-pig tracheal strips (GPTS) from actively sensitized animals with an IC50of 6 microM. in vivo: Additionally, while total tau levels were unchanged for both groups, zileuton-treated mice had a significant reduction in its phosphorylation state and insoluble forms, secondary to a decreased activation of the cdk5 kinase. Neurological deficit scores, infarct volume, and neuronal damage were significantly attenuated by administration of zileuton. MCAO caused the elevation of neuronal apoptosis, which was significantly inhibited by the administration of zileuton. MCAO ca
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