去甲二氢愈创木酸

  • 化学数据
CAS号 500-38-9 货号 BCP08590
中文名 去甲二氢愈创木酸
英文名 Nordihydroguaiaretic acid
中文别名
英文别名 NDGA;Masoprocol;
分子式 C18H22O4 分子量 302.36
  • 用途
生物活性 Nordihydroguaiaretic acid, also known as NDGA, is a naturally occurring antioxidant dicatechol originally derived from the creosote bush Larrea divaricatta with antipromoter, anti-inflammatory, and antineoplastic activities. NDGA directly inhibits activation of two receptor tyrosine kinases (RTKs), the insulin-like growth factor receptor (IGF-1R) and the c-erbB2/HER2/neu receptor, resulting in decreased proliferation of susceptible tumor cell populations. This agent may induce apoptosis in susceptible tumor cell populations as a result of disruption of the actin cytoskeleton in association with the activation of stress activated protein kinases (SAPKs). In addition, NDGA inhibits arachidonic acid 5-lipoxygenase (5LOX), resulting in diminished synthesis of inflammatory mediators such as prostaglandins and leukotrines; it may prevent leukocyte infiltration into tissues and the release of reactive oxygen species and, at higher concentrations, may also inhibit cyclooxygenase.
信号通路 Protease/Metabolic Enzyme 
靶 点 Lipoxygenase 

结构式

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