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CAS号 | 273404-37-8 | 货号 | BCP02893 |
中文名 | 贝尔纳卡桑 | ||
英文名 | Belnacasan | ||
中文别名 | |||
英文别名 | VX-765;VX 765;VX765; | ||
SMILES | CCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl | ||
化学名称 | |||
分子式 | C24H33ClN4O6 | 分子量 | 508.99 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Belnacasan (VX-765) is an orally bioactive proagent of VRT-043198, which is a potent and selective inhibitor of IL-converting enzyme (ICE)/caspase-1 with Kis of 0.8 nM and less than 0.6 nM for caspase-1 and caspase-4, respectively. Belnacasan (VX-765) inhibits the release of LPS-induced IL-1β and IL-18 by human PBMCs with an IC50 of ~0.7 μM. |
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