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CAS号 | 254750-02-2 | 货号 | BCP07463 |
中文名 | 恩利卡生 | ||
英文名 | PF03491390 | ||
中文别名 | |||
英文别名 | Emricasan;IDN6556;IDN 6556;IDN-6556;PF-03491390;PF 03491390; | ||
SMILES | |||
化学名称 | |||
分子式 | C26H27F4N3O7 | 分子量 | 569.5 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Emricasan, also known as IDN 6556 and PF 03491390, is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. IDN6556 facilitates marginal mass islet engraftment in a porcine islet autotransplant model. Oral IDN-6556 may lower aminotransferase activity in patients with chronic hepatitis C. Orally-administered PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model. |
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