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SG2057 结构式

SG2057

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货号 :BCP46387CAS号 :260417-62-7纯度:98%
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  • 基本信息与产品描述
CAS号 260417-62-7 货号 BCP46387
中文名 SG2057
英文名 SG2057
中文别名
英文别名 SG-2057; SG 2057;
SMILES COC1=C(C=C2C(=C1)C(=O)N3CC(=C)CC3C=N2)OCCCCCOC4=C(C=C5C(=C4)N=CC6CC(=C)CN6C5=O)OC
化学名称
分子式 C33H36N4O6 分子量 584.66
纯度 98% 配送 惯例下常温包邮
产品描述 SG2057 is a pentyldioxy linked PBD dimer which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts, and also mono-adducts depending on sequence. SG2057 has multilog differential in vitro cytotoxicity against a panel of human tumour cell lines with a mean GI(50) of 212 pM. The agent is highly efficient at producing DNA interstrand cross-links in cells which form rapidly and persist over a 48 h period. Significant antitumor activity was demonstrated in several human tumor xenograft models.
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