SG2057

  • 化学数据
CAS号 260417-62-7 货号 BCP46387
中文名 SG2057
英文名 SG2057
中文别名
英文别名 SG-2057; SG 2057;
分子式 C33H36N4O6 分子量 584.66
  • 用途
生物活性 SG2057 is a pentyldioxy linked PBD dimer which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts, and also mono-adducts depending on sequence. SG2057 has multilog differential in vitro cytotoxicity against a panel of human tumour cell lines with a mean GI(50) of 212 pM. The agent is highly efficient at producing DNA interstrand cross-links in cells which form rapidly and persist over a 48 h period. Significant antitumor activity was demonstrated in several human tumor xenograft models.
信号通路 Cell Cycle/DNA Damage Others Pathway 
靶 点 DNA Alkylator/Crosslinker ADC Related 

结构式

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