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| CAS号 | 1595275-71-0 | 货号 | BCP46386 |
| 中文名 | SG3199 | ||
| 英文名 | SG3199 | ||
| 中文别名 | |||
| 英文别名 | SG-3199; SG 3199; | ||
| SMILES | CC1=CN2C(C1)C=NC3=CC(=C(C=C3C2=O)OC)OCCCCCOC4=C(C=C5C(=C4)N=CC6CC(=CN6C5=O)C)OC | ||
| 化学名称 | |||
| 分子式 | C33H36N4O6 | 分子量 | 584.66 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | SG3199 is a PBD dimer warhead component of antibody-drug conjugate (ADC) payload tesirine, demonstrates potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines with mean GI50 of 151.5 pM; high-efficiently causes DNA interstrand cross-links in cancer cells; ADCT-402 (loncastuximab tesirine) is a novel CD19-targeted ADC delivering SG3199, ADCT-402 is highly potent, dose-dependent antitumor activity in several subcutaneous and disseminated human tumor models with marked superiority to comparator ADCs delivering tubulin inhibitors. | ||
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