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CAS号 | 2559703-06-7 | 货号 | BCP42606 |
中文名 | Apostatin-1 | ||
英文名 | Apostatin-1 | ||
中文别名 | |||
英文别名 | Apostatin1; Apostatin 1; Apt-1; Apt1; Apt 1; | ||
SMILES | CN1CCN=C1SC(C2=CC=CC=C2)C(=O)NC3CCCCCC3 | ||
化学名称 | |||
分子式 | C19H27N3OS | 分子量 | 345.51 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Apostatin-1 is a novel TRADD inhibitor.Apostatin-1 inhibits RIPK1-dependent apoptosis (RDA) with IC50 of 1.28 μM and shows no significant off-target activity on 97 kinases in KINOME scan profiling.Inhibition of TRADD by Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin. Treatment with Apt-1 restored proteostasis and inhibited cell death in a mouse model of proteinopathy induced by mutant tau(P301S). |
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