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Apostatin-1 结构式

Apostatin-1

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货号 :BCP42606CAS号 :2559703-06-7纯度:98%
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  • 基本信息与产品描述
CAS号 2559703-06-7 货号 BCP42606
中文名 Apostatin-1
英文名 Apostatin-1
中文别名
英文别名 Apostatin1; Apostatin 1; Apt-1; Apt1; Apt 1;
SMILES CN1CCN=C1SC(C2=CC=CC=C2)C(=O)NC3CCCCCC3
化学名称
分子式 C19H27N3OS 分子量 345.51
纯度 98% 配送 惯例下常温包邮
产品描述 Apostatin-1 is a novel TRADD inhibitor.Apostatin-1 inhibits RIPK1-dependent apoptosis (RDA) with IC50 of 1.28 μM and shows no significant off-target activity on 97 kinases in KINOME scan profiling.Inhibition of TRADD by Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin. Treatment with Apt-1 restored proteostasis and inhibited cell death in a mouse model of proteinopathy induced by mutant tau(P301S).
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