Apostatin-1
| CAS号 | 2559703-06-7 | 货号 | BCP42606 |
| 中文名 | Apostatin-1 | ||
| 英文名 | Apostatin-1 | ||
| 中文别名 | |||
| 英文别名 | Apostatin1; Apostatin 1; Apt-1; Apt1; Apt 1; | ||
| 分子式 | C19H27N3OS | 分子量 | 345.51 |
| 生物活性 | Apostatin-1 is a novel TRADD inhibitor.Apostatin-1 inhibits RIPK1-dependent apoptosis (RDA) with IC50 of 1.28 μM and shows no significant off-target activity on 97 kinases in KINOME scan profiling.Inhibition of TRADD by Apostatin-1 blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin. Treatment with Apt-1 restored proteostasis and inhibited cell death in a mouse model of proteinopathy induced by mutant tau(P301S). | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | Autophagy | ||
结构式
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