恩利卡生

  • 化学数据
CAS号 254750-02-2 货号 BCP07463
中文名 恩利卡生
英文名 PF03491390
中文别名
英文别名 Emricasan;IDN6556;IDN 6556;IDN-6556;PF-03491390;PF 03491390;
分子式 C26H27F4N3O7 分子量 569.5
  • 用途
生物活性 Emricasan, also known as IDN 6556 and PF 03491390, is a first-in-class caspase inhibitor in clinical trials for the treatment of liver diseases. Emricasan (IDN-6556) decreases liver injury and fibrosis in a murine model of non-alcoholic steatohepatitis. IDN6556 facilitates marginal mass islet engraftment in a porcine islet autotransplant model. Oral IDN-6556 may lower aminotransferase activity in patients with chronic hepatitis C. Orally-administered PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model.
信号通路 Protease/Metabolic Enzyme Apoptosis Pathway 
靶 点 Caspase 

结构式

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