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| CAS号 | 2244678-29-1 | 货号 | BCP31775 |
| 中文名 | TH-257 | ||
| 英文名 | TH-257 | ||
| 中文别名 | |||
| 英文别名 | TH257; TH 257; | ||
| SMILES | CCCCN(CC1=CC=CC=C1)C(=O)C2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC=C3 | ||
| 化学名称 | |||
| 分子式 | C24H26N2O3S | 分子量 | 422.54 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | TH-257 is a potent inhibitor of LIMK1 and LIMK2 with IC50 values of 84 nM and 39 nM for LIMK1 and LIMK2, respectively, and it can be used as a chemical probe for LIMK1 and LIMK2. TH-257 is an allosteric inhibitor targeting a binding pocket induced by an αC and DFG-out conformation. TH257 is exquisitely selective and no significant activity against the wider kinome has been observed in the KINOMEscan assay at 1 μM. | ||
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