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CAS号 | 205242-62-2 | 货号 | BCP49052 |
中文名 | NAS-181 methanesulfonate | ||
英文名 | NAS-181 methanesulfonate | ||
中文别名 | |||
英文别名 | NAS 181 methanesulfonate; NAS181 methanesulfonate; | ||
SMILES | CS(=O)(=O)O.CS(=O)(=O)O.C1COC(CN1)COC2=CC=CC3=C2OCC(=C3)CN4CCOCC4 | ||
化学名称 | |||
分子式 | C21H34N2O10S2 | 分子量 | 538.63 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | NAS-181 methanesulfonate is a 5-HT(1B) receptor antagonist.NAS181 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors. |
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