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Deschloroclozapine 结构式

去氯氮平

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP46891CAS号 :1977-07-7纯度:98%
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  • 基本信息与产品描述
CAS号 1977-07-7 货号 BCP46891
中文名 去氯氮平
英文名 Deschloroclozapine
中文别名
英文别名 DCZ;Dopamine serotonin antagonist-1;
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3NC4=CC=CC=C42
化学名称
分子式 C18H20N4 分子量 292.38
纯度 98% 配送 惯例下常温包邮
产品描述 Deschloroclozapine is a high affinity and highly potent activator of muscarinic DREADDs. It is a derivative of clozapine, and exhibits 100-fold greater affinity for hM3Dq and hM4Di compared to clozapine N-oxide, and 50-fold greater affinity compared to DREADD agonist 21. Deschloroclozapine displays low 'off-target' receptor binding and rapid binding and activation of hM3Dq and hM4Di in mice and non-human primates. It also induces spatial memory deficits in non-human primates expressing hM4Di in the prefrontal cortex.
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