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CAS号 | 1977-07-7 | 货号 | BCP46891 |
中文名 | 去氯氮平 | ||
英文名 | Deschloroclozapine | ||
中文别名 | |||
英文别名 | DCZ;Dopamine serotonin antagonist-1; | ||
SMILES | CN1CCN(CC1)C2=NC3=CC=CC=C3NC4=CC=CC=C42 | ||
化学名称 | |||
分子式 | C18H20N4 | 分子量 | 292.38 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | Deschloroclozapine is a high affinity and highly potent activator of muscarinic DREADDs. It is a derivative of clozapine, and exhibits 100-fold greater affinity for hM3Dq and hM4Di compared to clozapine N-oxide, and 50-fold greater affinity compared to DREADD agonist 21. Deschloroclozapine displays low 'off-target' receptor binding and rapid binding and activation of hM3Dq and hM4Di in mice and non-human primates. It also induces spatial memory deficits in non-human primates expressing hM4Di in the prefrontal cortex. |
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