去氯氮平
CAS号 | 1977-07-7 | 货号 | BCP46891 |
中文名 | 去氯氮平 | ||
英文名 | Deschloroclozapine | ||
中文别名 | |||
英文别名 | DCZ;Dopamine serotonin antagonist-1; | ||
分子式 | C18H20N4 | 分子量 | 292.38 |
生物活性 | Deschloroclozapine is a high affinity and highly potent activator of muscarinic DREADDs. It is a derivative of clozapine, and exhibits 100-fold greater affinity for hM3Dq and hM4Di compared to clozapine N-oxide, and 50-fold greater affinity compared to DREADD agonist 21. Deschloroclozapine displays low 'off-target' receptor binding and rapid binding and activation of hM3Dq and hM4Di in mice and non-human primates. It also induces spatial memory deficits in non-human primates expressing hM4Di in the prefrontal cortex. | ||
信号通路 | Neuro Signaling Pathway GPCR/G Protein | ||
靶 点 | mAChR |
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服:
- 全国免费电话:400-099-8200
瀚香生物(Biochempartner) 的所有产品和服务仅用于科学研究,禁止用于人体和治疗!