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| CAS号 | 187739-60-2 | 货号 | BCP34906 |
| 中文名 | Carboxyamidotriazole Orotate | ||
| 英文名 | Carboxyamidotriazole Orotate | ||
| 中文别名 | |||
| 英文别名 | L-651582 Orotate; CAI Orotate; L 651582; L-651582; L651582; NSC 609974; NSC609974; NSC-609974; | ||
| SMILES | C1=CC(=CC=C1C(=O)C2=C(C=C(C=C2Cl)CN3C(=C(N=N3)C(=O)N)N)Cl)Cl.C1=C(NC(=O)NC1=O)C(=O)O | ||
| 化学名称 | |||
| 分子式 | C23H16Cl3IN7O6 | 分子量 | 580.76 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Carboxyamidotriazole orotate is t he orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores, resulting in the disruption of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis. | ||
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