Carboxyamidotriazole Orotate

  • 化学数据
CAS号 187739-60-2 货号 BCP34906
中文名 Carboxyamidotriazole Orotate
英文名 Carboxyamidotriazole Orotate
中文别名
英文别名 L-651582 Orotate; CAI Orotate; L 651582; L-651582; L651582; NSC 609974; NSC609974; NSC-609974;
分子式 C23H16Cl3IN7O6 分子量 580.76
  • 用途
生物活性 Carboxyamidotriazole orotate is t he orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores, resulting in the disruption of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis.
信号通路 Ion Channel/Membrane Transporter 
靶 点 Calcium Channel 

结构式

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