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Belzutifan

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货号 :BCP32143CAS号 :1672668-24-4纯度:98%
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  • 基本信息与产品描述
CAS号 1672668-24-4 货号 BCP32143
中文名 Belzutifan
英文名 Belzutifan
中文别名
英文别名 MK-6482; MK 6482; MK6482; PT2977; PT-2977; PT 2977;
SMILES CS(=O)(=O)C1=C2C(C(C(C2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)F)F)O
化学名称
分子式 C17H12F3NO4S 分子量 383.34
纯度 98% 配送 惯例下常温包邮
产品描述 Belzutifan, also known as PT2977 and MK-6482, is HIF-2alpha inhibitor. PT2977 binds to and blocks the function of HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate hypoxic signaling. This inhibits cell growth and survival of HIF-2alpha-expressing tumor cells. HIF-2alpha, the alpha subunit for the heterodimeric transcription factor HIF-2, is overexpressed in many cancers and promotes tumorigenesis. Belzutifan was approved in 2021 for treatment of von Hippel-Lindau disease under certain conditions
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