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Desidustat 结构式

德度司他

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货号 :BCP29692CAS号 :1616690-16-4纯度:98%
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  • 基本信息与产品描述
CAS号 1616690-16-4 货号 BCP29692
中文名 德度司他
英文名 Desidustat
中文别名
英文别名 Zyan-1;Zyan 1;Zyan1;
SMILES O=C(O)CNC(C1=C(O)C2=C(N(OCC3CC3)C1=O)C=CC=C2)=O
化学名称
分子式 C16H16N2O6 分子量 332.31
纯度 98% 配送 惯例下常温包邮
产品描述 Desidustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor (HIF-PHI), with potential anti-anemic and anti-inflammatory activities. Upon administration, desidustat binds to and inhibits HIF-PH, an enzyme responsible for the degradation of transcription factors in the HIF family under normal oxygen conditions. This prevents HIF breakdown and promotes HIF activity. Increased HIF activity leads to an increase in endogenous erythropoietin production, thereby enhancing erythropoiesis. It also reduces the expression of the peptide hormone hepcidin, improves iron availability, and boosts hemoglobin (Hb) levels. HIF regulates the expression of genes in response to reduced oxygen levels, including genes required for erythropoiesis and iron metabolism. In addition, HIF 1-alpha (HIF1A) may play a role in reducing inflammation during acute lung injury (ALI) through HIF-dependent control of glucose metabolism in the alveolar epithelium.
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