Belzutifan
CAS号 | 1672668-24-4 | 货号 | BCP32143 |
中文名 | Belzutifan | ||
英文名 | Belzutifan | ||
中文别名 | |||
英文别名 | MK-6482; MK 6482; MK6482; PT2977; PT-2977; PT 2977; | ||
分子式 | C17H12F3NO4S | 分子量 | 383.34 |
生物活性 | Belzutifan, also known as PT2977 and MK-6482, is HIF-2alpha inhibitor. PT2977 binds to and blocks the function of HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate hypoxic signaling. This inhibits cell growth and survival of HIF-2alpha-expressing tumor cells. HIF-2alpha, the alpha subunit for the heterodimeric transcription factor HIF-2, is overexpressed in many cancers and promotes tumorigenesis. Belzutifan was approved in 2021 for treatment of von Hippel-Lindau disease under certain conditions | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
靶 点 | HIF |
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服:
- 全国免费电话:400-099-8200
瀚香生物(Biochempartner) 的所有产品和服务仅用于科学研究,禁止用于人体和治疗!