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CAS号 | 1352879-65-2 | 货号 | BCP25843 |
中文名 | PF-3450074 | ||
英文名 | PF-3450074 | ||
中文别名 | |||
英文别名 | PF74; PF-74; PF 74; PF 3450074; PF3450074; | ||
SMILES | CC1=C(C2=CC=CC=C2N1)CC(=O)NC(CC3=CC=CC=C3)C(=O)N(C)C4=CC=CC=C4 | ||
化学名称 | |||
分子式 | C27H27N3O2 | 分子量 | 425.52 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | PF-3450074 (PF74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153. |
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